aneurIST Glossary
@neuCompute
One of two service platforms for integration of heterogeneous data and computing resources (@neuCompute & @neuInfo), @neuCompute is a facility for distributed computing and secure data transport services.
@neuEndo
One of a set of four scalable and reusable integrative suites (@neuLink, @neuFuse, @neuRisk and @neuEndo), @neuEndo will build upon the technology of @neuFuse and a complex processing chain to deliver an innovative IT system for supporting the design of implantable devices and intervention planning by simulation of the structural, haemodynamic and biological response to intervention. The system will have access to a COTS (commercially off the shelf) repository of implant devices and allow virtual stenting and coiling on patient-specific anatomies with the goal of personalised selection of endovascular treatment options. Additionally, the platform will include advanced numerical simulation tools for predicting device-induced thrombosis and drug elution processes.
@neuFuse
One of a set of four scalable and reusable integrative suites (@neuLink, @neuFuse, @neuRisk and @neuEndo), @neuFuse will build upon and extend a Multimodal Application Framework (MAF) that will provide an open source environment to fuse diagnostic data and modelling data into a coherent representation of the patient's condition. It will allow the medical professional to interactively visualise all these data, using multiple display modalities and data types. Finally, this application will allow simulation and data steering from/to other suites (@neuCompute and @neuInfo) in order to obtain predictive simulations using all available patient- and domain-specific data. Underlying technologies will be state-of-the-art image segmentation, multimodal registration, and advanced visualisation.
@neuInfo
One of two service platforms for integration of heterogeneous data and computing resources (@neuCompute & @neuInfo), @neuInfo is a suite for distributed heterogeneous data access and semantic mediation and querying.
@neuLink
One of a set of four scalable and reusable integrative suites (@neuLink, @neuFuse, @neuRisk and @neuEndo), @neuLink will create an IT environment for the identification of candidate genes associated with the disease phenotype and for the integrated analysis of genetic epidemiology and clinical data. Moreover, @neuLink will provide a template for the planning of new genetic epidemiology studies. It will deliver a platform for providing text mining services, disease models, and data mining technology for the identification of candidate genes that will lead to the development of molecular diagnostics (SNPs).
@neuRisk
One of a set of four scalable and reusable integrative suites (@neuLink, @neuFuse, @neuRisk and @neuEndo), @neuRisk will produce a personalised risk assessment by integrating all available information, at all levels of abstraction, to produce a quantitative score for the individual and personalised guidelines by building upon and extending the PROforma knowledge modelling language to cope with heterogeneous and multi scale information integration. The objective is to provide the evidence required to reduce unnecessary interventions by 50%, with concomitant reduction of patient risk and economic savings.
Integration – High Level Integration
The conclusions drawn from diverse studies need to be combined into a unified disease model. High level integration is focused on (1) whether the conclusions inferred in one environment can be generalized to another environment and (2) how diverse, sometimes partial or even competing explanations can be combined into a single overall model. High level integration requires a perspective - that is, in order to combine evidence, an outcome needs to be defined that will be used to structure and simplify the domain. For clinicians, the perspective is often the prediction of certain outcomes.
Integration – Horizontal Integration
Integration at every level of abstraction, from access to information sources, to complex information processing, knowledge representation, structuring and fusion
Integration – Low Level Integration
The integration of diverse data sources into a single, coherent environment that allows researchers to combine data. Typically concerns itself with issues such as data format, ontology, interoperability and security issues.
Integration – Vertical Integration
Integration across data structures and across length scales (molecular, cellular, tissue, organ, individual and population).
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